PhD position in Gene Regulation - Gambetta lab (Lausanne, Switzerland)
The Gambetta lab is recruiting a Postdoctoral researcher to study how genome architecture impacts gene regulation in development.
The advertised project addresses the fundamental question of how regulatory elements are guided to their target genes. You will study a paradigm we uncovered in which genes are controlled by regulatory elements located at flexible and surprising large genomic distances. This model is powerful and unique.
You will use genetics (Drosophila genome-engineering, genetic screens, comparative evolution), genomics (transcriptomics, chromatin accessibility, chromosome conformation capture, genome-wide screens, single-cell genomics), imaging (fixed and live), and biochemistry (proteomics).
This project will reveal new evolutionary perspectives into the relevance of 3D genome folding for correctly wiring genes to their regulatory elements. For more information on our research check our lab website: http://www.gambettalab.org
Expected start date in position : as soon as possible or to be agreed
Contract length : 1 year, renewable 2 x 2 years, maximum 5 years
You will use multidisciplinary approaches such as genomics, genetics, imaging, and/or biochemistry in the fruit fly Drosophila melanogaster. You will present your results during seminars with gene regulation research labs in Lausanne. You will collaborate with other labs in Lausanne and abroad. Full funding for the position is available, but application to fellowships is also expected.
You are a dynamic and rigorous scientist with a PhD degree in Biology or a related discipline. You have experience in genomics (next-generation sequencing library preparation), molecular biology, genetics, biochemistry or imaging. You are a critical thinker, a team player eager to participate in scientific discussions but able to work independently. You have a strong interest in developing your skills in multidisciplinary experimental strategies to understand basic mechanisms in gene regulation.
The Gambetta lab is hosted at the Center for Integrative Genomics (CIG) at the University of Lausanne (UNIL), a vibrant, well-funded institute with a focus on functional genomics and equipped with modern core facilities (see www.unil.ch/cig).
It is embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), the Swiss Institute of Bioinformatics, Ludwig Center for Cancer Research, university hospital, and a cluster of biotech companies flourishing in the larger lake Geneva area.
The Gambetta lab tightly networks with other gene regulation research laboratories at UNIL and EPFL, and collaborates with the on-site Bioinformatics Competence Center. There are regular possibilities to present and participate in local or international conferences and workshops. Hard and soft skill, and career development courses are offered on campus.
We offer a nice working place in a multicultural, diversified and dynamic academic environment.
Please email lab head Prof. Maria Cristina Gambetta [Please click the Apply button for the link or address].
Provide your CV, a brief description of your research experience, and why you think your research interests complement ours.