The Uhlirova Lab investigates the pleiotropic functions of the stress-inducible signalling pathways and downstream mechanisms orchestrating gene expression in the context of epithelial tissues and innate immune cells. We study how diverse stress signals modulate transcription factor and spliceosome activities during development and physiology and how malfunction of transcription and splicing machinery affects epithelial and immune cell behaviours and the interactions between the two systems during ageing and disease. We combine functional genetics in Drosophila and mouse models with molecular and cell biology techniques, biochemistry, omic approaches, and advanced microscopy.

We seek a highly motivated applicant (f/m/x) to play a central role in ongoing laboratory projects.

YOUR TASKS

• Investigate the mechanisms governing the development and functions of innate immune cells in both healthy and disease contexts.
• Research transcriptional control of innate immune cell plasticity and multinucleation.
• Explore the interplay between transcription and splicing during the development and activation of the innate immune system.
• Elucidate the mechanisms underlying immune cell-tissue interactions in both homeostasis and disease states. 

YOUR PROFILE

• Doctoral degree in Biology/Biochemistry/Biophysics or related areas of Life Sciences
• Motivation, curiosity and creativity, and a strong ability to solve problems through critical analytical thinking
• Keen interest in the mechanisms of signalling and regulation of gene expression in development and disease
• Proven ability to independently carry out research projects
• Excellent communication skills, fluency in English, sense for teamwork and unwavering commitment to high-quality research
• Strong background in genetics and molecular biology is essential
• Experience with multicellular model organisms (e.g. Drosophila, mouse)
• Experience with various imaging techniques and expertise in image analyses
• Knowledge of bioinformatics tools and hands-on experience in gene expression analyses

ABOUT THE POSITION

The position is available immediately on a full-time basis (39,83 hours per week). It is limited for two years with possibility for extension. If the applicant meets the relevant wage requirements and personal qualifications, the salary is based on remuneration group 13 TV-L of the pay scale for the German public sector.

HOW TO APPLY

Please apply online at https://jobportal.uni-koeln.de with proof of the required qualifications and the following documents without a photo:

• A cover letter describing your motivation to join our research group (1 page max.)
• Your academic Curriculum Vitae, including your publication list
• A statement on your scientific achievements (1 page max.)
• Contact information for two references
• Copies of your degree certificates

The reference number is Wiss2311-04.

The application deadline is 17.12.2023.

WE OFFER

• The opportunity to work in an interactive and international research group with access to state-of-the-art facilities
• A diverse working environment with equal opportunities
• Support in balancing work and family life
• Extensive advanced training opportunities

The University of Cologne is committed to equal opportunities and diversity. Women are especially encouraged to apply and will be considered preferentially in accordance with the Gender Equality Act of the State of North Rhine-Westphalia (LGG NRW). We also expressly welcome people with disabilities/special needs or of equal status.