We are seeking a motivated and enthusiastic developmental/cell biologist to investigate how morphogen signalling pathways are impacted by the ageing process and what role altered morphogen signalling plays in the loss of stem cell function and tissue renewal that occurs with ageing.

An age associated dysfunction of both Wnt and Hedgehog signalling has been implicated in the perturbation of stem cell dynamics, leading to a loss of tissue homeostasis and renewal, which are hallmarks of ageing. By elucidating precisely how these signalling pathways change with age the knowledge can be leveraged to combat the dysfunction of signalling that occurs in, and potentially drives, ageing and aged related diseases. The postholder will use the intestinal stem cell niche of Drosophila melanogaster as a model system to investigate how the signalling landscape of stem cell niches change with age and how other key signalling pathways implicated in the ageing process, such as mTOR and insulin, integrate with Wnt and Hedgehog signalling.

The successful candidate must have a PhD in biochemistry, cell/molecular biology, developmental biology, genetics or related biological disciplines, with a demonstrable track-record in academic research. Experience in basic molecular biology techniques (e.g., cloning, RNAi/CRISPR), and protein biochemistry is essential. Experience with Drosophila melanogaster (in particular the intestine), RNA sequencing and proteomic methodologies is desirable. The post holder should have excellent communication skills and work well as part of a team.

For further information and to apply please visit: https://babrahaminstitute.livevacancies.co.uk/#/job/details/216?target=frame

Informal enquiries can be addressed to Dr Ian McGough (Ian.McGough@babraham.ac.uk).

Funding for this post is expected to be available for 3 years in the first instance. A full job specification and role requirements can be found attached to this vacancy. 

Applicants for a Postdoctoral Research Scientist must hold a PhD or have their thesis submitted when commencing the post. Please note that you will be appointed on the starting salary of £30,000 per annum, if you have not yet been awarded your PhD.

Closing date for applications is Sunday 8th August 2021.