Post-Doc position (EG 13) in Cell Biology of Notch Signalling


The position is open in the Klein group:

The Klein lab is located in the Biology Department of the Heinrich-Heine-Universität Düsseldorf, Germany ( The main topic is the regulation of the activity of the Notch signaling pathway by the endosomal pathway. We are employing imaging, biochemistry, molecular biology, genetics and cell biological techniques to understand the various roles of the endosomal system in the regulation of the Notch activity in Drosophila and cell culture.

Beginning: January 2023

Duration: 3 years

Location: Heinrich-Heine Universität Düsseldorf (

Working time: 100%

Working area and tasks

The project addresses the role of the ubiquitylation-independent activation of the Notch ligands during Notch signalling. More precisely, we have discovered a novel ubiquitylation-independent function of the E3-ligase Neuralized during activation of the Notch pathway. The mechanism behind this novel mode of activation should be revealed.

You will enroll as a member of the Heinrich Research Academies (HeRA,

Your profile

The candidate has a Ph. D. in Natural Sciences, experience in cell biology and cell signaling and is familiar with the Drosophila model system and its techniques. Ideally, he has also experience in advanced imaging techniques, such as live imaging, and biochemistry.

 We offer

The candidate will be working in a creative and international environment created by experienced Drosophila groups with an interest ranging from neurobiology, metabolism to developmental and tumour biology.

How to apply/Contact

Please direct further questions and/or send your application (including a cover letter, CV, key records, references or reference contacts) and motivation letter in a single PDF file to Prof. Dr. Thomas Klein (



November 10, 2022