Project Details: Gastrointestinal (GI) tract cancers are amongst the most prevalent and lethal malignancies worldwide and in the UK, bowel cancer is the second biggest cause of cancer deaths. Using a genetic model and bioinformatics, we have identified a novel tumour suppressor gene, which protects against colorectal tumour development. Critically, the gene is encoded at the 1p22 locus which is deleted in almost a third of colorectal cancer cases, in addition to a range of other cancers. This project can help explain the reason for this recurrent loss which will have broad impact in cancer research.

In this project, we will explore tumour suppressor functions using state-of-the-art organoid culture models and the powerful genetic model, the fruit fly (Drosophila). The impact of targeting the new tumour suppressor on stem cells, tissue growth and cancer signalling pathway activity will be measured. As organoids and flies are amenable to genetic manipulation, this approach saves time and reduces use of mammalian cancer models. At the BCI, we also have access to extensive human colon cancer tissue banks to validate our findings directly in human samples.

Training and Support: The studentship will take place at Barts Cancer Institute under the supervision of Dr Angus Cameron and Dr Paulo Ribeiro. Dr Cameron is an expert in novel cancer drug targets, currently focussing on pancreatic and colorectal cancer. Dr Ribeiro is an expert in Drosophila as a model to explore tissue growth, morphology and cancer. The project will provide the candidate with extensive training in cancer models, genetics, biochemistry and bioinformatics, which are skills in high demand in academia and industry.

Barts Cancer Institute is a world-class cancer research institute in the UK, performing basic and clinical research. In 2018 the BCI joined the Francis Crick Institute, King’s and UCL to form the CRUK City of London Major Centre. Advanced Microscopy Imaging, pathology, tissue banks and bioinformatics complete a robust infrastructure to deliver this project.

Further details and information on how to apply can be found at:

https://www.bartscancer.london/about/vacancies/using-organoids-and-drosophila-to-define-a-novel-colorectal-tumour-suppressor-gene-encoded-on-the-frequently-deleted-1p22-locus/