PhD Position: Exploring the Role of NOC1 in Cell Competition and DNA Damage Response

Project Description: We are seeking a highly motivated and talented PhD student to join our research team in investigating the intricate mechanisms of cell competition and the DNA damage response (DDR), focusing on the role of NOC1. This project delves into the fundamental processes that govern cell fate decisions and cellular fitness in development and disease.

Research Focus: Cell competition, an essential phenomenon in multicellular organisms, involves eliminating less fit cells by neighboring healthier cells. This process is crucial in tissue homeostasis, organ size regulation, and tumorigenesis. The DNA damage response is a complex network of signaling pathways that maintain genomic integrity and regulate cell cycle progression upon encountering DNA lesions.

Project Goals:

• Investigate the molecular mechanisms underlying NOC1-mediated cell competition.
• Elucidate the impact of NOC1 on cell fitness and survival during competitive interactions.
• Explore the interplay between NOC1 and the DNA damage response machinery.
• Determine the implications of NOC1 dysfunction in developmental abnormalities and disease states.

Methodologies: This project will employ a multidisciplinary approach, integrating molecular biology with live-cell imaging and bioinformatics analyses. The successful candidate will have the opportunity to work with cutting-edge technologies and collaborate with experts in the field.

Requirements:

• A Master's degree (or equivalent) in Molecular Biology, Cell Biology, Biochemistry, or a related field.