The Uhlirova Lab investigates the pleiotropic functions of the stress-inducible signaling pathways and downstream mechanisms
orchestrating gene expression in the context of epithelial tissues and innate immune cells. We study how diverse stress signals modulate transcription factor and spliceosome activities during development and physiology and how malfunction of transcription and splicing machinery affects epithelial and immune cell behaviors and the interactions between the two systems during aging and disease.

We seek doctoral candidates to join our efforts:

• To study the mechanisms governing the development and functions of the cellular branch of the innate immune system in health and disease.
• To elucidate the mechanisms underlying immune cell-tissue interactions in homeostasis and disease states.
• To study the crosstalk between transcription and splicing during innate immune system development and activation.
• To investigate how spliceosome malfunction impacts hematopoiesis and innate immune cell responses during infection and inflammatory diseases.

Ph.D. Position:

The position is available as soon as possible on a part-time basis (65%) and is limited to three years. The salary
is based on remuneration group 13 TV-L on the pay scale for the German public sector.

Your Profile:

• Master of Science or equivalent in Biology, Biochemistry, or Biophysics
• Strong background in genetics and molecular biology is essential
• Keen interest in the mechanisms of signaling and regulation of gene expression in the development and disease
• Motivation, curiosity, and problem-solving skills
• Ability to drive the project with a high degree of independence
• Fluency in English, sense for teamwork and commitment to high-quality research
• Experience with model organisms, imaging techniques, and knowledge of basic bioinformatics tools are welcome

Our Location:

The Uhlirova Lab is affiliated with the Institute for Genetics/Department of Biology/University of Cologne and the CECAD Cluster of Excellence in Aging Research. Our Lab is located at the CECAD Research Center and benefits from the interactive, diverse, and international academic environment with access to state-of-the-art research facilities.

How to Apply

Please apply online at https://jobportal.uni-koeln.de under the reference Wiss2306-01 with proof of the required qualifications and the following documents

• a Cover Letter describing your motivation to join our research group
• your academic Curriculum Vitae without a photo, including your publications and contact information for two references
• a statement on your scientific achievements, a summary (1/2 page) of your Master Thesis project or equivalent
• copies of your degree certificates

The application deadline is June 25, 2023.

Please direct any inquiries and questions to uhlirova-jobs@uni-koeln.de