PhD position in Drosophila Cell Biology of Notch Signalling


PhD position in Drosophila Cell Biology of Notch Signalling

The positions are open in the Klein group:


The Klein lab is located in the Biology Department of the Heinrich-Heine-Universität Düsseldorf, Germany ( The main topic is the regulation of the activity of the Notch signaling pathway by the endosomal pathway. We are employing bioimaging, biochemistry, molecular biology, genetics and cell biological techniques to understand the various roles of the endosomal system in the regulation of the Notch activity in Drosophila and cell culture.

Beginning: January 2022, or later

Duration: 3-4 years

Location: Heinrich-Heine Universität Düsseldorf (

Working time: 100%

Working area and tasks

The project addresses the role of ubiquitylation of the ligands and their endocytosis during activation of the Notch receptor. You will enroll as a member of the Heinrich Research Academies (HeRA,

Your profile

The ideal candidate has a Master Degree in Natural Sciences, interest in cell biology and cell signaling and is familiar with the Drosophila model system and its techniques. Ideally, he has also experience with advance imaging techniques, such as live imaging.


 We offer

The candidate will be working in a creative and international environment embedded in an experienced team of Drosophila groups ranging from neurobiology, metabolism to developmental and tumour biology. In an ongoing collaboration with the university hospital, the candidate is allowed to take part in seminars and newest findings on tumour biology.

How to apply/Contact

Please direct further questions and/or send your application (including a cover letter, CV, key records, references or reference contacts) and motivation letter in a single PDF file to Prof. Dr. Thomas Klein (


December 10, 2021